Dr. Umesh Srikantha

Sr. Consultant - Neurosurgery, Head of Spine Services

Neurosurgery

Aster RV Hospital - Bangalore, India

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Qualification

MBBS, M.Ch Neurosurgery, Fellowship in Minimally Invasive Spine Surgery

Languages

English

Work Experience

22 Years

Research Experience

• During my Neurosurgery residency
I worked as a co-investigator in a study to assess the efficacy of a novel drug AP12009 (TGF-?2 antisense phosphorothioate oligonucleotide – Inhibitor of TGF-?2)
presently known as ‘Trabedersen’ in recurrent high grade gliomas. It was called “a multi-national
multi-center
open-label
active-controlled
randomized parallel-group dose-finding study to evaluate the efficacy and safety of two doses of AP 12009 in adult patients with recurrent high-grade glioma
administered intratumorally as continuous high-flow microperfusion over a 7-day period every other week”. The study was funded by Anti-sense Pharma
Germany and was co-ordinated in India by SIRO Clinpharm Pvt. Ltd
Mumbai. There were 14 test subjects from our centre (NIMHANS
Bangalore).
• During my Neurosurgery residency
I was associated with a multi institutional project on “A prospective study to correlate gene signatures with clinical outcome of astrocytomas and identification of potential therapeutic target(s) in glioblastoma”. The project was funded by the Council for Scientific and Industrial Research (CSIR)
Government of India. In this project
I assisted in analyzing the association of certain novel glioblastoma biomarkers with the clinical progression and survival of patients with glioblastoma. This led to some of our publications on glioblastoma biomarkers in peer reviewed cancer journals such as ‘Clinical Cancer Research
Cancer Biology and therapy”.
• During my Neurosurgery residency
I was involved in a study to evaluate the clinical
histological features and expression of immunohistochemical markers in medulloblastoma
and to correlate these features with recurrence rates. The most important predictors of recurrence were extent of resection
chemotherapy
presence of gross anaplasia
and c-erb B2 over expression which formed the composition of a clinical-histological-immunohistochemical’ model for medulloblastoma proposed in our study. This work was submitted to NIMHANS as a dissertation in partial fulfillment of the requirements for the M.Ch degree
and also has been published in British Journal of Neurosurgery.

Awards & Achivements

Silver Jubilee Award for the ‘Best Outgoing Student’ of M.Ch in Neurosurgery from NIMHANS
Bangalore for the year 2008.

Memberships

• Neurological Society of India - NSI
• Bangalore Neurological Society – BNS
• Indian Medical Association – IMA (Bangalore)

Area of Interest

• Minimally Invasive/ Endoscopic Spine Surgery
• Neuro-oncology
• Stereotactic and Functional Neurosurgery

Dr. Umesh Srikantha is a highly acclaimed neurosurgeon working as a Senior Consultant and Head of spine services at Aster CMI Hospital. His areas of special interest are Minimally Invasive Spine Surgery, Endoscopic Spine surgery, complex spine surgery, Stereotactic, Functional Neurosurgery, and Neuro-oncology. He did his MBBS from Karnataka Institute of Medical Sciences, Hubli, Karnataka, followed by M.Ch training in Neurosurgery from the National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka. After working as a general neurosurgeon for a few years, he developed an active interest in the field of spine surgery and further pursued his training by doing a Fellowship in Minimally Invasive Spine Surgery from South Korea. Apart from attending various training programs on MIS in the early days of his career, he is also trained in stereotactic and functional neurosurgery and neuro-oncology. He has been a part of several research projects on brain tumors as well. An ever-enthusiastic professional, he has participated in various programs, attended a number of national and international conferences, and has several publications to his credit. He has conducted several workshops and has trained several surgeons from across the country in Minimally invasive spine surgery.